Main Researcher: Katharina M. Main
Other Researchers: Senior researcher group GR
Objective: The main aim is to explore whether biochemical and genetic markers of the hypothalamus-pituitary-gonadal (HPG) axis and clinical reproductive parameters in infancy predict adult male reproductive health including testosterone-dependent secondary health parameters such as body composition, bone health and metabolism. In addition, the study will explore whether fetal exposure to endocrine disrupting chemicals has irreversible adverse effects on male reproductive health in adulthood.
Description: This project is an adult follow-up of a prospective mother-child birth cohort including 1100 Danish boys and 800 girls born 1997-2001. The boys were repetitively seen for seven clinical examinations in childhood and puberty (anthropometry, penile length, testis size and descent), a bio bank was established (placenta, breast milk, serum from pregnant mothers, repetitive serum and urine from the child) and data from repetitive prenatal and postnatal questionnaires (education, nutrition, medical history, leisure activity, recreational drugs, psychomotor development) were obtained. During puberty two whole body DXA scans were performed. All boys from the original cohort will be invited at the age of 18-20 years for a follow-up examination.
Outcomes: semen quality, sex hormones, metabolism, cardiovascular parameters, bone health and body composition.
Status: Ethical permission has been obtained and the study will start at the end of 2017.