Main Researcher: Katharina M. Main
Other Researchers: Niels E. Skakkebæk, Professor Jorma Toppari, Helena Virtanen, Marie Tysman and colleagues (Turku, Finland)
Objective: to evaluate whether prenatal exposure to a cocktail of persistent environmental chemicals with suspected endocrine-disrupting properties is associated with hypospadias.
Description: This prospective nested case-control uses the joint Danish-Finnish birth cohort. Maternal breast milk samples were collected between 1997-2001 representing boys born with hypospadias (n=33) and controls (n=228). Breast milk samples were analyzed for 9 groups of persistent organic pollutants (POPs): PCDDs [Dioxins], PCDFs [Furans], Coplanar PCBs, Noncoplanar PCBs, PCBs, PBDEs, PBBs, HBCDs and PFCs. Breast milk measurements are used as proxy for prenatal exposure due to the long half live of these POPs.
Outcome: association between exposure levels to persistent environmental chemicals and the risk of giving birth to a boy with hypospadias.
Publications: in progress.