Normal and dysregulated human fetal adrenal development and function - EDMaRC

Go to content

Main menu:

Normal and dysregulated human fetal adrenal development and function

Research
Main Researcher: Cecilie Melau, PhD student

Other Researchers: 
John Erik Nielsen, Hanne Frederiksen, Anna-Maria Andersson, Anders Juul, Anne Jørgensen
 
Objective: To characterize normal and dysregulated human fetal adrenal endocrine function followed by the establishment of a dynamic ex vivo culture model for congenital adrenal hyperplasia.
 
Description: The human fetal adrenal is a steroid hormone producing organ that plays an important role in sexual differentiation of fetal gonads as well as in the overall endocrine function of the fetus. We hypothesize that both normal and dysregulated adrenal steroidogenesis in the human fetus can be investigated using a novel ex vivo tissue culture approach. The main aim of this project is to increase the understanding of adrenal function in human fetal development and establish a much needed model for normal fetal adrenals and for fetal congenital adrenal hyperplasia in which effects of manipulations on steroidogenesis can be examined.
 
Output: Characterization of the normal expression pattern of steroidogenic enzymes and determination of steroid metabolites in human fetal adrenals from 1st and 2nd trimester is almost completed. In addition, the establishment of specific culture conditions for human fetal adrenal ex vivo culture model has been initiated.
 
Publications: A manuscript characterizing normal human fetal adrenal endocrine function during 1st and 2nd trimester is in preparation. 
 
 
Back to content | Back to main menu