Prenatal Exposure to Phenols in Danish Children - EDMaRC

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Prenatal Exposure to Phenols in Danish Children

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Main Researcher: Hanne Frederiksen
MSc, PhD, Senior Scientist and chemist

Other Researchers: Anders Juul, Anna-Maria Andersson, Marianna Krause, Niels Erik Jørgensen
Objective: To elucidate the possible impact of exposure to phenols, parabens and UV filters on pubertal development in healthy children and adolescents.
Description: Danish girls enter puberty earlier than just a few decades ago and today about half of all Danish boys have transient breast development in puberty (pubertal gynecomastia). We are all exposed to thousands of industrial chemicals in everyday life, some of which are endocrine disruptors and are suspected to affect growth and endocrine balance before and during puberty. Previously, we have observed that exposure to phthalates, which are known for their anti-androgenic effects, were significantly associated with the time of pubic hair development in both boys and girls.
In this project we investigate whether other suspected endocrine disrupting chemicals, which are known to have estrogenic effects (in vitro and/or in animal studies), also disturb puberty, specifically premature breast development in girls and transient breast development in boys.
The Copenhagen Puberty Study offers a unique material of cross-sectional and longitudinal cohort data, including medical assessment of health and pubertal stage, growth and hormone status in more than 2000 Danish children and adolescents.
In the present project more than 1600 urine samples collected longitudinally during a seven year period from 168 children are currently being analyzed for the content of phenols, parabens and UV filters, all suspected endocrine disrupting chemicals.

Outcome: The chemical analysis will be finished in the end of 2016. The first preliminary data of possible influence of the phenols bisphenol A, triclosan and benzophenon-3 on growth and pubertal development was presented at “1st African Conference on health effects of endocrine disruptors”, 2-6 November 2015.
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