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EDC Exposure In-Utero and Testicular Function in Offspring (EDC-TF)
January 2022 – December 2028
It is estimated that 15-20% of all couples suffer from infertility, of which male factor infertility (MFI) is a major contributing cause. According to the testicular dysgenesis syndrome hypothesis, it has been proposed that MFI has a fetal origin and may be a result of testicular insults during early fetal development, including exposure to endocrine disrupting chemicals (EDCs).
Aims and Study Design
The overall aim of EDC-TF is to investigate the prospective association between prenatal exposures to individual and cocktail EDCs with testicular function (semen quality and sex hormones) in young adulthood and MFI in late adulthood, focusing on exposures in serum collected in second trimester of pregnancy. The primary target population is men who participated in the Danish Young Male Study (DYMS), a well-characterized cohort of 5,000 males born in 1980-1996 with individual data on semen quality, sex hormone levels, anthropometrics and lifestyle collected from the males while being considered for military services at age 18 years.
The project will utilize access to Danish nationwide health registries and a unique collection of maternal biosamples (gold standard) collected from mothers during the index pregnancy 22-42 years ago.
The project will further aim to understand alterations in metabolic reprogramming in the early development of testicular function and identify novel metabolomic fetal biomarkers that serve as indictors of reduced testicular function or MFI in later life.
The Research Group behind EDC-TF
The international research group behind EDC-TF consist of leading scientist in multidisciplinary fields of male reproductive health, endocrinology, biostatistics, epidemiology, exposure assessment and analytical chemistry. Apart from participants from EDMaRC (Anders Juul (PI), Niels Jørgensen, Lærke Priskorn, Cecilie Skaarup Uldbjerg, Astrid Linnea Beck) other partners include Elvira Bräuner, the Danish Statens Serum Institut (Madeleine Ernst, Francesco Russo), the Danish National Biobank, (Karina Meden Sørensen), TC Chan School of Public Health, Harvard University, USA (Russ Hauser, Brent Coull) and Lund University, Sweden (Christian Lindh) and Institute for Health and Welfare, Finland (Panu Rantakokko).
Key EDMaRC researchers involved in the project:
MDSc, Professor
MD, PhD, Senior Researcher
Dept. of Growth and Reproduction
Copenhagen University Hospital, Rigshospitalet
Blegdamsvej 9
DK-2100 Copenhagen Denmark

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