Longitudinal exposure to EDCs and effects on sexual maturation – the COPENHAGEN Puberty Study - EDMaRC

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Longitudinal exposure to EDCs and effects on sexual maturation – the COPENHAGEN Puberty Study

Main Researcher: Hanne Frederiksen and Anders Juul

Other Researchers: 
Anna-Maria Andersson and Niels E. Skakkebæk 
Objective: Environmental chemicals such as chemical UV filters as benzophenone-1 (BP-1) and benzophenone-3 (BP-3), some parabens, bisphenol A (BPA), triclosan (TCS) and other phenols are suspected to have estrogenic and/or anti-androgenic effects. However, little is known about their potential effects on puberty timing and development. Therefore we evaluated the potential association between nine UV filters, seven parabens and eight phenols and their potential associations to puberty timing in the COPENHAGEN Puberty Study  

Description: In the longitudinal cohort of the COPENHAGEN Puberty Study, 215 healthy girls and boys (aged 5.6 to 11.8 years at baseline) were followed longitudinally with examinations every 6 months for 7.5 years. Blood and first morning urinary samples were collected at each examination for determination of serum concentrations of sex steroids and the amount of urinary excreted chemicals.

Outcome:  In a total of 1525 longitudinal urine samples, BP-3, BPA, TCS and 3 parabens were measured in almost all samples (> 90%), BP-1 and 2,4-dichlorophenol were measured in > 75% of samples, while two other parabens as well as 2,5-dichlorophenol and 4-phenylphenol were measured in > 50% of the samples. Although exposure levels varied, each individual demonstrated her/his own specific exposure level and followed their own individual exposure pattern both before and during puberty.
Output: Data are in the process of statistical analysis and will be evaluated in association to hormone levels and pubertal status such as breast and pubic hair development (girls) and testicular volume, pubic hair and breast development (boys).

Publications: in preparation
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