Long-term Health Consequences following Pre-Menopausal Oophorectomy: a Prospective Register-based Cohort Study
September 2018 – December 2028
Oophorectomy is an optional procedure where one (unilateral) or both (bilateral) ovaries are surgically removed. The procedure is often performed as a risk reducing procedure among women with high inherited risk of ovarian cancer. Female sex hormones including estrogen have long-lasting cardiovascular protective, neuroprotective, and anti-ageing properties. Removal of the ovaries in premenopausal women leads to an abrupt cessation of estrogen production causing premenopausal menopause and presumably altering the long-term health risks for these women. It is well-known that premenopausal oophorectomy aggravates vasomotor symptoms, but it is uncertain how the procedure affects long-term health as current evidence is limited.
Aims and Study Design
The overall aim is to investigate the long-term health consequences following pre-menopausal oophorectomy including cancer (breast and colorectal) risk assessment, mental health effects, mortality, and fracture risk. The study is based on the Danish Nurse Cohort established in 1993 and re-investigated in 1999. All newly recruited nurses completed self-administered questionnaires including information on working shift patterns, lifestyle factors (including smoking, and alcohol consumption), education, occupation, parity, age at menarche, oral contraceptive use, medical history, self-reported height and weight, and use of hormone therapy. We have access to the entire cohort data of 28,731 women and have linked these to national health registries with relevant information on exposure (oophorectomy), confounding and outcome variables (cancers, mental health, fracture, and death).
The Research Group
The project is conducted in collaboration with the Christian Dehlendorff and Jane Christensen from the Danish Cancer Society, Zorana Andersen and Youn-Hee Lim from University of Copenhagen, Denmark, Professor Martha Hickey from University of Melbourne, Australia, Louise F. Wilson from University of Queensland, Australia, Julie Abildgaard from Centre for Physical Activity Research, Rigshospitalet, Denmark and Mette K. Simonsen from Diakonissestiftelsen and Parker Institute, Frederiksberg Hospital, Denmark. Involved partners from EDMaRC, Department of Growth and Reproduction, Rigshospitalet, Denmark include Professor Anders Juul, Elvira V. Bräuner, Lærke Priskorn, Cecilie S. Uldbjerg and Trine K. Hueg.
Key senior EDMaRC researchers involved in the project: