Precocious puberty - registry study - EDMARC

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Health Prior to and After a Diagnosis of Precocious Puberty
January 2020 – December 2027
Precocious Puberty is defined as the development of secondary sexual characteristics before age 8 years for girls and 9 years for boys and is more commonly diagnosed in girls compared to boys. Classical central precocious puberty (CPP) is defined by premature development of secondary sex characteristics, acceleration of linear growth, advanced bone age, and a pubertal response to a gonadotropin-releasing hormone test. By contrast, premature thelarche (PT) is defined as a self-limiting isolated breast development associated with a normal growth rate, and bone age corresponding to chronological age and prepubertal response to a stimulation GnRH test. Premature adrenarche (PA) is a condition characterized by premature pubic hair development (pubarche), normal growth rate, and mild elevations of adrenal androgens, after exclusion of serious adrenal disorders (congenital adrenal hyperplasia or adrenal carcinoma). Both premature thelarche and premature adrenarche are benign forms of PP and are associated with normal height potential and age at menarche.
Aims and Study Design
The overall aim of the project is to investigate health prior to and following a diagnosis of precocious puberty (CPP, PT, PA and overall).
We will use Danish registries recognized for validity and completeness including:
- Central Population Registry
- National Patient Registry/patient Registry for Psychiatry
- Cancer Registry
- Prescription Registry
- Medical Birth Registry
We have created a cohort of over 51,576 children (girls/boys: 46,620/4,956) registered with an incident diagnosis of CPP, PT or PA (8,596) and age- and calendar-matched children with no diagnosis (n=42,980) from the background population. Children with precocious puberty were stratified into those without (idiopathic) or those with a pre-existing recognized risk factor.
Cox and logistic regression models will be used to investigate disease risk following and prior precocious puberty (CPP, PT, PA, overall) diagnosis, respectively.

MDSc, Professor
Dept. of Growth and Reproduction
Copenhagen University Hospital, Rigshospitalet
Blegdamsvej 9
DK-2100 Copenhagen Denmark

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