Prenatal risk factors for female reproductive health - EDMaRC

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Prenatal risk factors for female reproductive health


Main Researcher: P.I.: Katharina M. Main. Ph.D.-student: Maria Assens

Other Researchers: Hanne Frederiksen, Anna-Maria Andersson, Anette T√łnnes Pedersen (The Fertility Clinic), Shanna H. Swan (Mt. Sinai collaborator)
Objective: This project aims at investigating prenatal risk factors for female reproductive health by examining adolescent daughters of an existing longitudinal mother-child cohort of 850 girls established and followed since 1997-2001. We hypothesize that both prenatal exposure to modern environmental chemicals and maternal life style during pregnancy may influence pubertal development, ovarian development and follicle reserve, which in turn determines reproductive life span.
Description: The adolescent daughters in the Copenhagen Mother-Child cohort were examined anthropometrically and by transabdominal 3D ovarian ultrasound primarily on day 2-5 during the menstrual cycle. Blood, urine and hair samples were collected and hormonal profiles and analysis of genetic polymorphisms will be carried out. Biobank samples allow chemical exposure measurements during prenatal life, i.e. during critical developmental windows, for relevant endocrine-disrupting chemicals. Blood samples from infancy and childhood enable the establishment of early biomarkers of female reproductive potential. 
Outcome: All examinations and collection of biological samples were finalized in 2015-2016. Hormonal and chemical analyses of prenatal and pubertal serum samples were carried out 2016-2017. Analyses of data are in progress and results are expected published in 2017.
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