Danish Young Men Study - EDMARC

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Publications based on the Young Male Reproductive Health Study:
Last updated August 2023           printable pdf version
1. López Krabbe HV, Holm Petersen J, Asserhøj LL et al. Reproductive hormones, bone mineral content, body composition and testosterone therapy in boys and adolescents with Klinefelter syndrome. Endocr Connect. 2023 [Online ahead of print].
2. Pedersen MK, Bräuner E V., Hansen AH, et al. Self-Reported Asthma Is Associated with Reduced Sperm Count—A Cross-Sectional Study of More than 6000 Young Men from the General Population. Life. 2023;13(2):278. (doi:10.3390/life13020278).
3. Hansen LS, Priskorn L, Holmboe SA, et al. Testicular function is associated with cardiometabolic health markers: A cross-sectional study of 2289 young men. Andrology. 2023:561-574. (doi:10.1111/andr.13365).
4. Hansen AH, Priskorn L, Hansen LS, et al. Testicular torsion and subsequent testicular function in young men from the general population. Hum Reprod. 2023;38(2):216-224. (doi:10.1093/humrep/deac271).
5. Vogel N, Frederiksen H, Lange R, et al. Urinary excretion of phthalates and the substitutes DINCH and DEHTP in Danish young men and German young adults between 2000 and 2017 – A time trend analysis. Int J Hyg Environ Health. 2023;248:114080. (doi:10.1016/j.ijheh.2022.114080).
6. Nordkap L, Almstrup K, Priskorn L, et al. Hair cortisol, glucocorticoid gene receptor polymorphisms, stress, and testicular function. Psychoneuroendocrinology. 2022;146. (doi:10.1016/j.psyneuen.2022.105942).
7. Kortenkamp A, Scholze M, Ermler S, et al. Combined exposures to bisphenols, polychlorinated dioxins, paracetamol, and phthalates as drivers of deteriorating semen quality. Environ Int. 2022;165. (doi:10.1016/j.envint.2022.107322).
8. Priskorn L, Kreiberg M, Bandak M, et al. Testicular cancer survivors have shorter anogenital distance that is not increased by 1 year of testosterone replacement therapy. Hum Reprod. 2021;36(9):2443-2451. (doi:10.1093/humrep/deab162).
9. Nassan FL, Priskorn L, Salas-Huetos A, et al. Association between intake of soft drinks and testicular function in young men. Hum Reprod. 2021;36(12):3036-3048. (doi:10.1093/humrep/deab179).
10. Frederiksen H, Krause M, Jørgensen N, Rehfeld A, Skakkebæk NE, Andersson AM. UV filters in matched seminal fluid-, urine-, and serum samples from young men. J Expo Sci Environ Epidemiol. 2021;31(2):345-355. (doi:10.1038/s41370-020-0209-3).
11. Priskorn L, Joensen UN, Petersen JH, Jensen TK, Skakkebaek NE, Jørgensen N. Familial resemblance in markers of testicular function in fathers and their young sons: A cross-sectional study. Hum Reprod. 2021;36(3):543-550. (doi:10.1093/humrep/deaa314).
12. Bang AK, Almstrup K, Nordkap L, et al. FSHB and FSHR gene variants exert mild modulatory effect on reproductive hormone levels and testis size but not on semen quality: A study of 2020 men from the general Danish population. Andrology. 2021;9(2):618-631. (doi:10.1111/andr.12949).
13. Nordkap L, Priskorn L, Bräuner E V., et al. Impact of psychological stress measured in three different scales on testis function: A cross-sectional study of 1362 young men. Andrology. 2020;8(6):1674-1686. (doi:10.1111/andr.12835).
14. Nassan FL, Jensen TK, Priskorn L, Halldorsson TI, Chavarro JE, Jørgensen N. Association of Dietary Patterns With Testicular Function in Young Danish Men. JAMA Netw Open. 2020;3(2):e1921610. (doi:10.1001/jamanetworkopen.2019.21610).
15. Koch T, Hansen AH, Priskorn L, et al. A history of cryptorchidism is associated with impaired testicular function in early adulthood: A cross-sectional study of 6376 men from the general population. Hum Reprod. 2020;35(8):1765-1780. (doi:10.1093/humrep/deaa127).
16. Jensen TK, Priskorn L, Holmboe SA, et al. Associations of Fish Oil Supplement Use With Testicular Function in Young Men. JAMA Netw open. 2020;3(1):e1919462. (doi:10.1001/jamanetworkopen.2019.19462).
17. Holmboe SA, Priskorn L, Jensen TK, Skakkebaek NE, Andersson AM, Jørgensen N. Use of e-cigarettes associated with lower sperm counts in a cross-sectional study of young men from the general population. Hum Reprod. 2020;35(7):1693-1701. (doi:10.1093/humrep/deaa089).
18. Frederiksen H, Krause M, Jørgensen N, Rehfeld A, Skakkebæk NE, Andersson A-M. UV filters in matched seminal fluid-, urine-, and serum samples from young men. J Expo Sci Environ Epidemiol. Published online February 12, 2020. (doi:10.1038/s41370-020-0209-3).
19. Frederiksen H, Nielsen O, Koch HM, et al. Changes in urinary excretion of phthalates, phthalate substitutes, bisphenols and other polychlorinated and phenolic substances in young Danish men; 2009–2017. Int J Hyg Environ Health. 2020;223(1):93-105. (doi:10.1016/j.ijheh.2019.10.002).
20. Anvari Aria S, Nordström Joensen U, Bang AK, et al. Testicular microlithiasis on scrotal ultrasound in 4850 young men from the general population: associations with semen quality. Andrology. 2020;8(6):1736-1743. (doi:10.1111/andr.12854).
21. Priskorn L, Petersen JH, Jørgensen N, et al. Anogenital distance as a phenotypic signature through infancy. Pediatr Res. 2018;83(3):573-579. (doi:10.1038/pr.2017.287).
22. Bang AK, Busch AS, Almstrup K, et al. Is the FSHR 2039A>G variant associated with susceptibility to testicular germ cell cancer? Andrology. 2018;6(1):176-183. (doi:10.1111/andr.12440).
23. Aksglaede L, Olesen IA, Carlsen E, Petersen JH, Juul A, Jørgensen N. Serum concentration of anti-Müllerian hormone is not associated with semen quality. Andrology. 2018;6(2):286-292. (doi:10.1111/andr.12456).
24. de Neergaard R, Nielsen JE, Jørgensen A, Toft BG, Goetze JP, Jørgensen N. Positive association between cholesterol in human seminal plasma and sperm counts: results from a cross-sectional cohort study and immunohistochemical investigations. Andrology. 2018;6(6):817-828. (doi:10.1111/andr.12532).
25. Joensen UN, Jørgensen N, Thyssen JP, Bela P, Stender S. Urinary excretion of phenols , parabens and benzophenones in young men : Associations to reproductive hormones and semen quality are modi fi ed by mutations in the Filaggrin gene. Environ Int. 2018;121(May):365-374. (doi:10.1016/j.envint.2018.09.020).
26. Andreassen M, Juul A, Feldt-Rasmussen U, Jørgensen N. Semen quality in patients with pituitary disease and adult-onset hypogonadotropic hypogonadism. Endocr Connect. 2018;7(4):523-533. (doi:10.1530/EC-18-0061).
27. Priskorn L, Nordkap L, Bang AK, et al. Average sperm count remains unchanged despite reduction in maternal smoking: results from a large cross-sectional study with annual investigations over 21 years. Hum Reprod. 2018;33(6):998-1008. (doi:10.1093/humrep/dey090).
28. Nordkap L, Almstrup K, Nielsen JE, Bang AK, Priskorn L, Krause M, Holmboe SA, Winge SB, Egeberg Palme DL, Mørup N, Petersen JH, Juul A, Skakkebaek NE, Rajpert-De Meyts E, Jørgensen N. Possible involvement of the glucocorticoid receptor (NR3C1) and selected NR3C1 gene variants in regulation of human testicular function. Andrology. 2017 Nov;5(6):1105-1114.(doi: 10.1111/andr.12418).
29. Mørup N, Busch AS, Bang AK, Nordkap L, Nielsen JE, Rajpert-De Meyts E, Juul A, Jørgensen N, Almstrup K. Polymorphisms in JMJD1C are associated with pubertal onset in boys and reproductive function in men. Sci Rep. 2017 Dec 8;7(1):17242. (doi: 10.1038/s41598-017-17575-9).
30. Priskorn L, Jensen TK, Bang AK, Nordkap L, Joensen UN, Lassen TH, Olesen IA, Swan SH, Skakkebaek NE, Jørgensen N. Is Sedentary Lifestyle Associated With Testicular Function? A Cross-Sectional Study of 1,210 Men. Am J Epidemiol. 2016 Aug 15;184(4):284-94. (doi: 10.1093/aje/kwv338).
31. Damsgaard J, Joensen UN, Carlsen E, Erenpreiss J, Blomberg Jensen M, Matulevicius V, Zilaitiene B, Olesen IA, Perheentupa A, Punab M, Salzbrunn A, Toppari J, Virtanen HE, Juul A, Skakkebæk NE, Jørgensen N. Varicocele Is Associated with Impaired Semen Quality and Reproductive Hormone Levels: A Study of 7035 Healthy Young Men from Six European Countries. Eur Urol. 2016 Dec;70(6):1019-1029. (doi: 10.1016/j.eururo.2016.06.044).
32. Jensen TK, Finne KF, Skakkebæk NE, Andersson AM, Olesen IA, Joensen UN, Bang AK, Nordkap L, Priskorn L, Krause M, Jørgensen N, Juul A. Self-reported onset of puberty and subsequent semen quality and reproductive hormones in healthy young men. Hum Reprod. 2016 Aug;31(8):1886-94. (doi: 10.1093/humrep/dew122).
33. Jørgensen N, Joensen UN, Toppari J, Punab M, Erenpreiss J, Zilaitiene B, Paasch U, Salzbrunn A, Fernandez MF, Virtanen HE, Matulevicius V, Olea N, Jensen TK, Petersen JH, Skakkebæk NE, Andersson AM. Compensated reduction in Leydig cell function is associated with lower semen quality variables: a study of 8182 European young men. Hum Reprod. 2016 May;31(5):947-57. (doi: 10.1093/humrep/dew021).
34. Parra MD, Mendiola J, Jørgensen N, Swan SH, Torres-Cantero AM. Anogenital distance and reproductive parameters in young men. Andrologia. 2016 Feb;48(1):3-10. (doi: 10.1111/and.12403).
35. Gundersen TD, Jørgensen N, Andersson AM, Bang AK, Nordkap L, Skakkebæk NE, Priskorn L, Juul A, Jensen TK. Association Between Use of Marijuana and Male Reproductive Hormones and Semen Quality: A Study Among 1,215 Healthy Young Men. Am J Epidemiol. 2015 Sep 15;182(6):473-81. (doi: 10.1093/aje/kwv135).
Gaskins AJ, Mendiola J, Afeiche M, Jørgensen N, Swan SH, Chavarro JE. Physical activity and television watching in relation to semen quality in young men. Br J Sports Med. 2015 Feb;49(4):265-70. (doi: 10.1136/bjsports-2012-091644).
37. Jensen TK, Swan S, Jørgensen N, Toppari J, Redmon B, Punab M, Drobnis EZ, Haugen TB, Zilaitiene B, Sparks AE, Irvine DS, Wang C, Jouannet P, Brazil C, Paasch U, Salzbrunn A, Skakkebæk NE, Andersson AM. Alcohol and male reproductive health: a cross-sectional study of 8344 healthy men from Europe and the USA. Hum Reprod. 2014 Aug;29(8):1801-9. (doi: 10.1093/humrep/deu118).
38. Jensen TK, Gottschau M, Madsen JOB, Andersson A-M, Lassen TH, Skakkebæk NE, Swan SH, Priskorn L, Juul A and Jørgensen N. Habitual alcohol consumption associated with reduced semen quality and changes in reproductive hormones; a cross-sectional study among 1,221 young Danish men. BMJ Open, 2014; 4: e005462 (doi:10.1136/bmjopen-2014-005462).
39. Søeborg T, Frederiksen H, Mouritsen A, Johannsen TH, Main KM, Jørgensen N, Petersen JH, Andersson A-M and Juul A. Sex, age, pubertal development and use of oral contraceptives in relation to serum concentrations of DHEA, DHEAS, 17-alpha-hydroxyprogesterone, delta-4-androstendione, testosterone and their ratios in children, adolescents and young adults. Clinica Chimica Acta, 2014; 437: 6-136 (doi: 10.1016/j.cca.2014.06.018).
40. Lassen TH, Frederiksen H, Jensen TK, Petersen JH, Joensen UN, Main KM, Skakkebæk NE, Juul A, Jørgensen N and Maria Andersson A-M. Urinary Bisphenol A levels in young men: Association with reproductive hormones and semen quality. Environmental Health Perspectives 2014; 122: 478-484 (doi: 10.1289/ehp.1307309).
41. Andreassen M, Jensen RB, Jørgensen N and Juul A. Association between GH receptor polymorphism (exon 3 deletion), serum IGF1, semen quality, and reproductive hormone levels in 838 healthy young men. European Journal of Endocrinol-ogy, 2014; 170: 555-563 (doi: 10.1530/EJE-13-0729).
42. Tinggaard J, Aksglæde L, Sørensen K, Mouritsen A, Wohlfahrt-Veje C, Hagen CP, Mieritz MG, Jørgensen N, Wolthers OD, Heuck C, Petersen JH, Main KM and Juul A. The 2014 Danish references from birth to 20 years for height, weight and body mass index. Acta Paediatrica 2014; 103: 214-224 (doi: 10.111/apa.12468).
43. Frederiksen H, Jensen TK, Jørgensen N, Husby S, Skakkebæk NE, Main KM, Juul A and Andersson A-M. Human urinary excretion of non-persistent environmental chemicals: an overview of Danish data collected 2006-2012. Reproduction 2014; 147: 555-565 (doi: 10.1530/REP-13-0522).
44. Krysiak-Baltyn K, Nordahl Petersen T, Audouze K, Jørgensen N, Ängquist L and Brunak S. Compass: a hybrid method for clinical and biobank data mining. Journal of Biomedical Informatics 2014; 47: 160-170 (doi: 10.1016/j.jbi.2013.10.007).
45. Kranich SK, Frederiksen H, Andersson A-M and Jørgensen N: Estimated daily intake and cumulative risk assessment of phthalate diesters for 33 young Danish men. Environmental Science and Technology, 2014; 48: 706-712 (doi:10.1021/es402569k).
46. Joensen UN, Jørgensen N, Meldgaard M, Frederiksen H, Andersson A-M, Menné T, Johansen JD, Carlsen BC, Szecsi PB, Skakkebæk NE, Rajpert-De Meyts E and Thyssen JP: Associations of fillagrin gene loss-of-function variants with urinary phthalate metabolites and testicular function in young Danish men. Environmental Health Perspectives, 2014; 122: 345–350 (doi: 10.1289/ehp.1306720).
47. Lassen TH, Frederiksen H, Jensen TK, Petersen JH, Main KM, Skakkebæk NE, Jørgensen N, Kranich SK and Andersson A-M: Temporal Variability in Urinary Excretion of Bisphenol A and Seven Other Phenols in Spot, Morning, and 24-hour Urine samples. Environmental Research 2013; 126; 164-170 (doi: 10.1016/j.envres.2013.07.001).
48. Christensen JS, Asklund C, Skakkebæk NE, Jørgensen N, Andersen HR, Jørgensen TM, Olsen LH, Høyer AP, Moesgaard J, Thorup J and Jensen TK: Association between organic dietary choice during pregnancy and hypospadias in offspring: A study of mothers of 306 boys operated for hypospadias. Journal of Urology, 2013; 189:1077-1082 (doi:10.1016/j.juro.2012.09.116).
49. Jensen TK, Andersson A-M, Skakkebæk NE, Joensen UN, Jensen MB, Lassen TH, Nordkap L, Hansen ÅM, Rod NH and Jørgensen N: Association of Sleep disturbances with reduced semen quality: A cross-sectional study among 953 healthy young Danish men. American Journal of Epidemiology, 2013; 177: 1027-1037 (doi:10.1093/aje/kws420).
50. Frederiksen H, Kranich SK, Jørgensen N, Taboureau O, Petersen JH and Andersson A-M: Temporal variability in urinary phthalate metabolite excretion based on spot, morning, and 24-hour urine samples: considerations for epidemiological studies. Environmental Science and Technology, 2013; 47: 958-967.
51. Joensen UN, Veyrand B, Antignac J-P, Jensen MB, Petersen JH, Marchand P, Skakkebæk NE, Andersson A-M, Le Bizec Band Jørgensen N: PFOS (perfluorooctanesulfonate) in serum negatively associated with testosterone levels in healthy men. Human Reproduction, 2013; 28: 599-608. (doi:10.1093/humrep/des425).
52. Jensen TK, Heitmann BL, Jensen MB, Halldorsson TH, Andersson A-M, Skakkebæk NE, Joensen UN, Lauritsen MP, Christiansen P, Dalgård C, Lassen TH and Jørgensen N: High dietary intake of saturated fat associated with reduced semen quality among 701 young Danish men from the general population. American Journal of Clinical Nutrition, 2013; 97:411-418 (doi: 10.3945/ajcn.112.042432).
53. Dalgaard MD, Weinhold N, Edsgärd D, Silver JD, Pers TH,Nielsen JE, Jørgensen N, Juul A, Gerds TA, Giwercman A,Giwercman YL, Cedermark GC, Virtanen HE, Toppari J, Daugaard G, Jensen TS, Brunak S, Rajpert-De Meyts E,Skakkebæk NE, Leffers H, Gupta R: A genome-wide association study of men with symptoms of testicular dysgenesis syn-drome and its net-work biology interpretation. Journal of Medical Genetics, 2012; 49: 58-65 (doi: 10.1136/jmedgenet).
54. Jensen MB, Jørgensen A, Nielsen JE, Bjerrum PJ, Skalkam M, Petersen JH, Bangsbøll S, Andersen AN, Skakkebæk NE,Juul A, Rajpert-De Meyts E, Dissing S, Leffers H and Jørgensen: 'Expression of the vitamin D metabolizing enzymeCYP24A1 at the annulus of human spermatozoa may serve as a novel marker of semen quality. International Journal of Andrology 2012, 35(4):499-510 (doi: 10.1111/j.1365-2605.2012.01256.x).
55. Jørgensen N, Joensen UN, Jensen TK, Jensen MB, Almstrup K, Olesen IA, Juul A, Andersson A-M, Carlsen E, Petersen JH, Toppari J and Skakkebæk NE: Human Semen Quality in the New Millennium. BMJ Open, 2012; 2: e000990 (doi:10.1136/bmjopen-2012-000990).
56. Joensen UN, Frederiksen H, Jensen MB, Lauritsen MP, Olesen IA, Lassen TH, Andersson A-M and Jørgensen N.Phthalate Excretion Pattern and Testicular Function: A Study of 881 Healthy Danish Men. Environmental Health Perspectives, 2012; 120: 1397-1403 (doi.org/10.1289/ehp.1205113).
57. Edsgärd E, Schell M, Hansen NT, Ralfkiær U, Jensen, TS, Skakkebæk NE, Brunak S, Gupta R, Rajpert-De Meyts E and Ottesen AM. Heterozygous deletion of the RLN1 locus in a family with testicular germ cell cancer identified by integratingcopy number variation data with phenome and interactome information. International Journal of Andrology, 2011; 34:e122-32 (doi: 10.1111/j.1365-2605.2011.01188.x.)
58. Jensen MB, Bjerrum PJ, Jessen TE, Nielsen JE, Joensen UN, Olesen IA, Petersen JH, Juul A, Dissing S and Jørgensen N. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. HumanReproduction, 2011; 26: 1307-1317 (doi:10.1093/humrep/der059).
59. Ravnborg T, Jensen TK, Andersson A-M, Toppari J, Skakkebæk NE and Jørgensen N. Prenatal and adult exposures to smoking are associated with adverse effects on reproductive hormones, semen quality, final height and body mass index.Human Reproduction, 2011; 26: 1000-1011 (doi: 10.1093/humrep/der011).
60. Jensen MB, Nielsen JE, Jørgensen A, Rajpert-De Meyts E, Kristensen DM, Jørgensen N, Skakkebæk NE, Juul A and Leffers H. Vitamin D receptor and the Vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Human Reproduction, 2010; 25: 1303-1311.
61. Frederiksen H, Jørgensen N and Andersson AM. Correlations between phthalate metabolites in urine, serum and seminal plasma from young Danish men determined by isotope dilution liquid chromatography tandem mass spectrometry. Journal of Analytical Toxicology, 2010; 34: 400-410.
62. Frederiksen H, Jørgensen N and Andersson A-M. Parabens in urine, serum and seminal plasma from healthy Danish men determined by liquid chromatography-tandem mass spectrometry (LC-MA/MS). Journal of Exposure Science and Environmental Epidemiology, 2010, 1-10 (doi: 10.1038/jes.2010.6).
63. Jensen TK, Swan SH, Skakkebæk NE, Rasmussen S and Jørgensen N. Caffeine intake and semen quality in a population of 2,554 young Danish men. American Journal of Epidemiology, 2010; 171: 883-891 (doi: 10.1093/aje/kwq007).
64. Jørgensen N, Rajpert-De Meyts E, Main KM and Skakkebæk NE. Testicular dysgenesis syndrome comprises some but not all cases of hypospadias and impaired spermatogenesis. International Journal of Andrology, 2010; 33: 298-303 (doi10.1111/j.1365-2605.2009.01050.x).
65. Asklund C, Jensen TK, Main KM, Sobotka T, Skakkebæk NE and Jørgensen N. Semen quality, reproductive hormones and fertility of men operated for hypospadias. International Journal of Andrology, 2010; 33: 80-87 (doi 10.1111/j.1365-2605.2009.00957.x.).
66. Joensen UN, Bossi R, Leffers H, Jensen AA, Skakkebæk NE and Jørgensen N. Do Perfluoroalkyl Compounds Impair Human Semen Quality? Environmental Health Perspectives, 2009; 6: 923-927. (doi: 10.1289/ehp.0800517).
67. Aksglæde L, Jørgensen N, Skakkebæk NE and Juul A. Low Semen Volume in 47 adolescents and adults with 47,XXY Klinefelter or 46,XX-male Syndrome. International Journal of Andrology, 2008; 32: 376-384.
68. Jensen MB, Leffers H, Petersen JH, Daugaard G, Skakkebaek NE, Rajpert-De Meyts E. Association of the polymorphism of the CAG repeat in the mitochondrial DNA polymerase gamma gene (POLG) with testicular germ cell cancer. Ann Oncol 2008; 19: 1910-1914.
69. Jensen TK, Jørgensen N, Asklund C, Carlsen E, Kristensen TS, Holm M and Skakkebæk NE. Self-rated health and semen quality among 3,457 young Danish men. Fertility and Sterility, 2007; 88: 1366-1373.
70. Jensen TK, Jørgensen N, Asklund C, Carlsen E, Holm M and Skakkebæk NE: Fertility Treatment and Reproductive Health of Male Offspring. A Study of 1,925 Young Men from the General Population. American Journal of Epidemiology, 2007;165: 583-590.
71. Bang AK, Carlsen E, Holm M, Petersen JH, Skakkebæk NE and Jørgensen N. A study of finger lengths, semen quality and sex hormones in 360 young men from the general Danish population. Human Reproduction, 2005; 20: 3109-3113.
72. Bay K, Hartung S, Ivell R, Schumacher M, Jørgensen N, Skakkebæk NE and Andersson AM. Insl3 serum levels in 135normal men and 82 men with testicular disorders: Relation to semen quality and the LH-testosterone axis. Journal of Clinical Endocrinology and Metabolism, 2005; 90: 3410-3418.
73. Jensen TK, Andersson AM, Jørgensen N, Andersen AG, Carlsen E, Petersen JH and Skakkebæk NE. Body mass index in relation to semen quality and reproductive hormones among 1,558 Danish men. Fertility and Sterility, 2004; 82: 863-870.
74. Jensen M, Leffers H, Petersen JH, Andersen AN, Jørgensen N, Carlsen E, Jensen TK, Skakkebæk NE, Rajpert-De Meyts E. Frequent polymorphism of the mitochondrial DNA polymerase gamma gene (POLG) in patients with normal spermiograms and unexplained subfertility. Hum Reprod 2004; 19: 65-70.
75. Jensen TK, Jørgensen N, Punab M, Haugen TB, Suominen J, Zilaitiene B, Andersen AG, Carlsen E, Magnus Ø, Matulevicius V, Nermoen I, Vierula M, Keiding N, Toppari J and Skakkebæk NE. Association of in utero exposure to maternal smoking with reduced semen quality and testis size in adulthood; A cross sectional study of 1770 young men from the general population in five European countries. American Journal of Epidemiology, 2004; 159: 49-58.
76. Jørgensen N, Carlsen E, Nermoen I, Punab M, Suominen J, Andersen AG, Andersson AM, Haugen TB, Horte A, Jensen TK, Magnus Ø, Petersen JH, Vierula M, Toppari J and Skakkebæk NE. East-west gradient in semen quality in the Nordic-Baltic area: A study of men from the general population in Denmark, Norway, Estonia and Finland. Human Reproduction, 2002; 17: 2199-2208.
77. Krausz C, Quintana-Murci L, Rajpert-De Meyts E, Jobling M, Jørgensen N, Larsen LF, Skakkebæk NE and McElreavey K. Identification of an Y-chromosome haplogroup associated with reduced sperm counts. Human Molecular Genetics, 2001;10: 1873-1877.
78. Krausz D, Rajpert-De Meyts E, Frydelund-Larsen L, Quintana-Murci L, McElreavey K and Skakkebæk NE. Double-Blind Y Chromosome Microdeletion Analysis in Men with Known Sperm Parameters and Reproductive Hormone Profiles: Microdeletions Are Specific for Spermatogenic Failure. Journal of Clinical Endocrinology and Metabolism, 2001; 86: 2638-2642.
79. Andersen AG, Jensen TK, Carlsen E, Jørgensen N, Andersson AM, Krarup T, Keiding N and Skakkebæk NE. High frequency of sub-optimal semen quality in an unselected population of young men. Human Reproduction, 2000; 15: 366-372.
Dept. of Growth and Reproduction
Copenhagen University Hospital, Rigshospitalet
Blegdamsvej 9
DK-2100 Copenhagen Denmark

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